End a game before it has even begun

GTA IV
When riding to America, Niko and all of the others illegal immigrants get caught by the coast guard and are sent back home

Heavy Rain
Actually knowing how to parent, Ethan holds Jason's hand throughout the mall

 

Super Mario Galaxy: Mario dies when he gets kamek-blasted.
Sonic Unleashed:Sonic doesn't survive the fall.
Kingdom Hearts: Sora doesn't check out the storm at the island.

 

Fallout New Vegas
You are shot in the head
You don't survive
The ****ing end

 

Bioshock

Guy Drowns .

 

Dark Cloud
They never reawaken the Dark Genie.

Final Fantasy 12
The guy survives, they manage to save the kingdom, and the war ends.

Shadow of The Collosus
The protagonist moves on with his dead lover and finds someone else.

Bioshock 2
Eleanor fails to re-awaken 'subject Delta'.

 

The Secret of Monkey Island: Guybrush becomes a mighty flooring inspector.

 

Dragon Age Origins

Your character drinks the taint of the Darkspawn, doesn't become a Grey Warden, and dies.

 

Burnout: When your car crashed you died.

 

Mass Effect:
Ashley: There's the beacon
Kaidin: Wow looks awesome
Ashley: It wasn't like that before, someone must have activated it *walks towards beacon*
Shepard: Ashley get the hell away from that that's an order!
Ashley: Yes commander
Sheapard never activates the beacon thus never sees the visions of the reapers and dose not know of the threat that is coming, the end.

 

Game spoilerer....

Halo: You don't wake up.

 

Mass Effect 2: Saren kills you in Mass Effect.

 

Kingdom Hearts: The Heartless overrun a back-water island in the middle of nowhere. A bunch of no-name kids die in the carnage. One of 'em jumps into the thing, the stupid bastard.

Kingdom Hearts 2: As Donald, Goofy, and Kairi make their escape from Hollow Bastion, Donald spots a stray Shadow following them and fries it with a single lightning bolt. They never figure out what happened to Sora.

Kingdom Hearts: Chain of Memories: Pluto guides our heroes down an unknown, but pleasant road, 'til they reach a foreboding castle. They have the good sense to go around it. Reverse/Rebirth: Some kid talks to himself in the middle of nowhere. The stupid bastard.

Kingdom Hearts: 358/2 Days: Some kid with spiky brown hair wakes up, dazed and confused, in a quaint little town. A spiky redhead in a black coat runs through on business, mistaking the kid for a Dusk and roasting him. Ah well, no harm done.

Kingdom Hearts: Re:Coded: Square Enix releases yet another novelty game based on a popular franchise. No one plays it.

Kingdom Hearts: Birth by Sleep: On his way to a Mark of Mastery exam being hosted by long-time friend Master Eraqus, Master Xehanort tragically collides with a planet. Some kids in white lab coats with weird hair colors clean up the mess.

 

EFF, I thought of that. But, I gawt zee back up.

Pokemon: Your character falls into coma while at home.
Gary has a level 100 Starter and whoops your a** at the first Pokemon battle.

World ends with you: Neku never dies. Shiki never enters the Game.

Tomb Raider: Laura Croft wants to be a Cat lady.

Final Fantasy X-2: Tidus never went missing, it was just a hoax. *HOORAY!*

 

Warhammer 40,000: Dawn of War (the original one): Captain Gabriel Angelos of the Blood Ravens Space Marine Chapter does what Inquisitor Toth says and leaves the planet Tartarus, thus screwing over the main villains plans and not releasing the deamon inside the Maledictum thus the events of later Dawn of War games would not happen (like Dawn of War: Soulstorm, Dawn of War II: Chaos Rising and Dawn of War II: Retribution).

I win.

*points to Darkspawn Chronicles DLC*

[video=youtube;tw72pngIYpE]http://www.youtube.com/watch?v=tw72pngIYpE[/video]

So yeah, you fail.

 

Ocarina of Time: Navi can't wake Link up before the Deku Tree Dies;
Ganondorf burns the Deku Tree;
Zelda kicks Link out of the castle, throwing him into the dungeon for sneaking into the castle.

Majora's Mask: Link doesn't feel like looking for his "Lost Friend", thought to be Navi;
Skull Kid never finds the Mask Salesman, and never steals Majora's Mask.

WindWaker: Link drowns

Twilight Princess: Link is trampled by Ordon Goats;
Rusl decides Link isn't ready to deliver something of much importance as the Ordon Shield and Sword;
King Bulbin kills Link instead of putting him in the dungeon;
Zelda calls the guards to kill a wolf that found its way into her room.